One console.
Every instrument talking.
A protein databank, a literature index, a variant archive, a chemistry database, a local compute bench, and a hash-chained lab notebook were never designed to speak to each other. The science runtime wires all of them into one console: ask in plain language, and every answer comes back pinned to the database, accession, and URL it came from. Connecting instruments that were never supposed to connect isn't a feature of this lab — it is the product.
Counts on this page are the shipped tool surface of the runtime's research server, exercised end-to-end by its adversarial harness. They are scale and coverage figures — not accuracy, discovery, or clinical claims.
An instrument is one callable tool exposed by the research server: 33 query instruments across 19 services, plus the compute bench and the 10-instrument WetHands lane. The harness drives the real server over the wire — happy paths, hostile inputs, degraded upstreams — and is scored inverted: a finding earns points, a pass earns zero.
Instruments that were never
meant to talk to each other.
Six benches, nineteen services, thirty-three query instruments — plus the native bench on the Airtight chapter. The mono line under each service names the exact tools it powers on the console.
Literature — 6 instruments
PubMed
Biomedical literature search — abstracts with PMIDs, DOIs, citations.
pubmed_search · pubmed_abstractsPubMed Central
Open-access full text, fetched by PMCID.
pmc_fulltext
arXiv
Preprints across quantitative biology and beyond.
arxiv_search
bioRxiv · medRxiv
Preprint feeds by date window; DOI fetch with the journal-published version when one exists.
biorxiv_recent · biorxiv_fetchScholarly graph — 4 instruments
Proteins & structures — 7 instruments
UniProt
Curated proteins — function, disease links, domains, sequence.
uniprot_search · uniprot_entry
RCSB PDB
Experimental structures — method, resolution, primary citation.
pdb_search · pdb_entryAlphaFold DB
Predicted structures for UniProt accessions, with confidence data.
alphafold_structureInterPro
Protein families, domains, and sites — and an honest zero when nothing matches.
interpro_domains · interpro_entryGenomes & variants — 9 instruments
Ensembl
Genes, coordinates, transcripts, FASTA sequence, cross-references.
ensembl_gene · ensembl_sequence · ensembl_xrefsEnsembl VEP
Predicted variant consequences from rsID or HGVS. Research use only.
vep_consequences
NCBI
Nucleotide and protein records — FASTA and GenBank.
ncbi_sequence_search · ncbi_fetch_sequenceClinVar
Variant classifications and review status, reported verbatim — never re-graded.
clinvar_search · clinvar_variantdbSNP
rsID records — location, genes, alleles.
dbsnp_variantChemistry — 4 instruments
Queried live through each service's public interface under the source contract. Service names belong to their respective owners; the marks above are our own text renderings, and no partnership or endorsement is implied. Variant and clinical instruments are for research use only.
How incompatible instruments
learn one language.
Ask
One question at the console. No per-service query languages, no tab-hopping between nineteen websites.
Route
Lois fans the question across the benches — literature, structures, variants, chemistry, pathways — and gathers what comes back.
Pin
Every result carries its source: database, accession, URL. A result that cannot name its source is refused by construction, not by convention.
Admit
The PEEL gate decides what enters the lab record. Clinical significance stays verbatim; unsupported claims stay out.
The air-gap posture
Live lanes query public interfaces when the wire exists. Everything the lab keeps — topic packs, the scientist ledger, the Peel graph — is local files that keep working with the cable pulled. Evidence is harvested into packs that ship offline, because a lab record has to stand on its own in a disconnected review.
The instruments, talking.
A short, unedited capture of a grounded research pass moving across the instrument wall — every fact pinned to its source database. Recorded on a research prototype.
Grounded discovery across the wall
Following typed relationships across services, in one console.