Search curated pathways
with stable identifiers.
Reactome is the expert-curated, peer-reviewed pathway knowledgebase — reactions and pathways modelled in detail, each with a stable R-HSA identifier. reactome_search puts it on the console, pinned to that ID, as a second curated view of biological process beside KEGG.
What the instrument does
Reactome is an open, manually-curated and peer-reviewed database of human pathways and reactions — molecular events organised into a navigable hierarchy, each with a stable identifier like R-HSA-70171.
On the console, reactome_search queries pathways, reactions and proteins by name or species and returns entries with their stable IDs — the anchor a pathway claim resolves against.
Tools this powers on the console
reactome_search
Research use only. Service names belong to their owners; no partnership or endorsement is implied.
How Perslis integrates Reactome
Reactome and KEGG both map biological process, but they curate it differently — reaction-level detail versus pathway maps — so the console keeps both rather than picking a winner. A question about glycolysis returns Reactome's R-HSA-70171 and KEGG's hsa00010, and an agent sees two independent curations of the same biology.
Because Reactome's proteins carry UniProt accessions, a pathway found here reaches back to the protein bench — the same anchor that ties structure, prediction and domains together, now placing a protein inside the reactions it participates in.
Ask
One question at the console — no per-service query language, no tab-hopping.
Route
Lois calls this instrument alongside the others and gathers what returns.
Pin
Every field keeps its source: database, accession, URL. A result that cannot name its source is refused by construction.
Admit
The PEEL gate decides what enters the lab record. Reported values stay verbatim; unsupported claims stay out.
A real, source-pinned result
Pulled live from the service and pinned to its identifier — the same contract every answer on the console is held to.
| Top pathway | Glycolysis |
|---|---|
| Stable ID | R-HSA-70171 |
| Type | Pathway |
| Species | Homo sapiens |
| Related | R-HSA-70326 Glucose metabolism |
Source: reactome · R-HSA-70171 · retrieved 2026-09-18
Why route Reactome through one console
Curated pathways, callable
An agent reaches peer-reviewed reactions pinned to stable R-HSA identifiers — no manual browsing.
A second curated view
Reactome answers alongside KEGG, so two independent curations of a pathway are both on the table.
Reaches back to proteins
Reactome proteins carry UniProt accessions, tying a pathway to the structure bench's anchor.
Instruments Reactome talks to
A curated pathway is one model of a process. Reactome answers beside KEGG and the protein anchor.
