Query UniProt
as the anchor for every protein.
UniProt is the curated reference for proteins — function, disease links, domains, sequence. On the console it is the anchor accession: a UniProt ID is the key that PDB, AlphaFold, InterPro and Ensembl all resolve against, so five databases describe one protein without you copying an ID between five tabs.
What the instrument does
UniProt (UniProtKB) is the expert-curated protein knowledgebase — reviewed entries with function, subcellular location, disease associations, sequence features and cross-references to structure and genome databases.
On the console, uniprot_search resolves a name or gene to accessions, and uniprot_entry returns the full record — function, disease, domains and its list of PDB structures — pinned to the accession.
Tools this powers on the console
uniprot_search · uniprot_entry
Research use only. Service names belong to their owners; no partnership or endorsement is implied.
How Perslis integrates UniProt
UniProt is the join key of the protein bench. Ask about hemoglobin and Lois resolves it to P69905, then that one accession fans out: its PDB cross-references become structure lookups, its sequence becomes an AlphaFold model, its features become InterPro domains. The instruments talk to each other because they share the UniProt anchor.
Curated disease text — alpha-thalassemia, Heinz body anemia — is reported verbatim from the entry, never paraphrased into something a model finds tidier. If UniProt says it, the console says it; if it does not, the console does not invent it.
Ask
One question at the console — no per-service query language, no tab-hopping.
Route
Lois calls this instrument alongside the others and gathers what returns.
Pin
Every field keeps its source: database, accession, URL. A result that cannot name its source is refused by construction.
Admit
The PEEL gate decides what enters the lab record. Reported values stay verbatim; unsupported claims stay out.
A real, source-pinned result
Pulled live from the service and pinned to its identifier — the same contract every answer on the console is held to.
| Entry | HBA_HUMAN — Hemoglobin subunit alpha |
|---|---|
| Organism | Homo sapiens (reviewed) |
| Genes | HBA1, HBA2 |
| Length | 142 aa |
| Domain | Globin (residues 2–142) |
| Disease | Alpha-thalassemia; Heinz body anemia |
| PDB structures | 300+ cross-referenced (e.g. 1HHO) |
Source: uniprot · P69905 · retrieved 2026-09-18
Why route UniProt through one console
The join key for proteins
One accession resolves against PDB, AlphaFold, InterPro and Ensembl — no ID copied between tabs.
Curated, callable
An LLM reaches reviewed function and disease text directly, structured, pinned to accession.
Verbatim, not paraphrased
Disease and function text is reported as UniProt wrote it — the console never tidies it into a fabrication.
Instruments UniProt talks to
One protein, five databases. From the UniProt anchor the console reaches structure, prediction, domains and gene.
RCSB PDB
Experimental structures — method, resolution, primary citation.
pdb_search · pdb_entryAlphaFold DB
Predicted structures for UniProt accessions, with confidence data.
alphafold_structureInterPro
Protein families, domains and sites — and an honest zero when nothing matches.
interpro_domains · interpro_entry
Ensembl
Genes, coordinates, transcripts, FASTA sequence, cross-references.
ensembl_gene · ensembl_sequence · ensembl_xrefs