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PERSLIS · PREDICTION ENGINE

Trial success predictor · spot the failure before general testing

5 programs scored · 2 flagged high-risk · calibrated on published base rates

Programs ranked by failure risk (worst first)

programphasesuccessverdictgrounded evidence
EZH2 · lymphomaphase_219%LIKELY FAILURE — spot it nowgenetic no · druggable yes · refs 6
CFTR · lymphomaphase_219%LIKELY FAILURE — spot it nowgenetic no · druggable yes · refs 6
CFTR · cystic fibrosisphase_238%PROCEED WITH CAREgenetic yes · druggable yes · refs 6
BCL2 · lymphomaphase_363%SUPPORTEDgenetic no · druggable yes · refs 6
HBB · sickle cell anemiaphase_390%SUPPORTEDgenetic yes · druggable yes · refs 6

What to reconduct next (portfolio-wide research to review again)

×3 — genetic validation — e.g. establish human genetic validation for EZH2 → lymphoma